Article

Comprehensive degron mapping in human transcription factors

2025-05-17

Abstract excerpt

Gene expression is regulated by the targeted degradation of transcription factors through the ubiquitin-proteasome system. Transcription factors destined for degradation are recognized by E3 ubiquitin-protein ligases through short motifs termed degrons, embedded within the sequence. In this study, we systematically map degrons in all 1,626 human transcription factors. We find thousands of both known and previously...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8f8be5c-a216-5743-bc63-75c250bd8d35
DOI: 10.1101/2025.05.16.654404

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive degron mapping in human transcription factorsDOI 10.1101/2025.05.16.654404Read

A complete map of human cytosolic degrons and their relevance for diseaseSemantic proximity Read

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read

Classification of Human Transcription Factors Based on Their Effector Domains via Unsupervised LearningSemantic proximity Read

A proteocistromic atlas of 216 human disease-relevant transcription factorsSemantic proximity Read

An expansive human regulatory lexicon encoded in transcription factor footprints.Semantic proximity Read

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factorsSemantic proximity Read

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations.Semantic proximity Read

Survey of variation in human transcription factors reveals prevalent DNA binding changes.Semantic proximity Read

DegronMD: Leveraging Evolutionary and Structural Features for Deciphering Protein-Targeted Degradation, Mutations, and Drug Response to Degrons.Semantic proximity Read

Factorbook: an Updated Catalog of Transcription Factor Motifs and Candidate Regulatory Motif SitesSemantic proximity Read

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associationsSemantic proximity Read

Detecting Differential Transcription Factor Activity from ATAC-Seq Data.Semantic proximity Read