Article

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations

2019-12-23

Abstract excerpt

DNA associated proteins (DAPs) classically regulate gene expression by binding to regulatory loci such as enhancers or promoters. As expanding catalogs of genome-wide DAP binding maps reveal thousands of loci that, unlike the majority of conventional enhancers and promoters, associate with dozens of different DAPs with apparently little regard for motif preference, an understanding of DAP association and coordinat...

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Literature Corpus work: 2d7c61e5-5d89-5817-abf6-bd6a3c58e627
DOI: 10.1101/2019.12.21.885830

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