Article
Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations.
Genome research - 1 Jul 2020
Ramaker Ryne C, Hardigan Andrew A, Goh Say-Tar, Partridge E Christopher, Wold Barbara, Cooper Sara J, Myers Richard M
Abstract excerpt
DNA-associated proteins (DAPs) classically regulate gene expression by binding to regulatory loci such as enhancers or promoters. As expanding catalogs of genome-wide DAP binding maps reveal thousands of loci that, unlike the majority of conventional enhancers and promoters, associate with dozens of different DAPs with apparently little regard for motif preference, an understanding of DAP association and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.