Article

Network Spreading and Local Biological Vulnerability in Amyotrophic Lateral Sclerosis

2024-04-15

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that predominantly targets the motor system. Spread of pathology is thought to be driven by both local vulnerability and network architecture. Namely, molecular and cellular features may confer vulnerability to specific neuronal populations, while synaptic contacts may also increase exposure to pathology in connected neuronal population...

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Literature Corpus work: 417b003c-53b6-51d6-9aa8-b2de851b9eef
DOI: 10.1101/2024.04.11.588760

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