Article

<i>CDH1</i> loss remodels gene expression and lineage identity in human mammary epithelial cells

2025-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Invasive lobular carcinoma (ILC) is a common subtype of breast cancer, molecularly defined by genetic loss of CDH1, and subsequent loss of cell adhesion protein E-cadherin, in ∼95% of ILC. Though CDH1 loss occurs early in ILC oncogenesis, it is unclear how this facilitates transformation. We modeled early CDH1 loss using “normal” human mammary epithelial cells (HMEC), i.e. finite lifespan cel...

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Literature Corpus work: c896d59f-5d0c-58c4-b8c0-397f44862490
DOI: 10.1101/2025.06.20.660633

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