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Article

Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer.

The Journal of pathology - 1 Apr 2009

Christgen Matthias, Bruchhardt Henriette, Hadamitzky Catarina, Rudolph Cornelia, Steinemann Doris, Gadzicki Dorothea, Hasemeier Britta, Römermann Daniel, Focken Tim, Krech Till, Ballmaier Matthias, Schlegelberger Brigitte, Kreipe Hans, Lehmann Ulrich

Abstract excerpt

Infiltrating lobular breast cancer (ILBC) is a clinically and biologically distinct tumour entity defined by a characteristic linear cord invasion pattern and inactivation of the CDH1 tumour suppressor gene encoding for E-cadherin. ILBCs also lack beta-catenin expression and show aberrant cytoplasmic localization of the E-cadherin binding protein p120-catenin. The lack of a well-characterized ILBC cell line has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19191266
DOI: 10.1002/path.2495

Genes

CDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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