Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells.

Cancer research - 15 Jan 2021

Chen Fangyuan, Ding Kai, Priedigkeit Nolan, Elangovan Ashuvinee, Levine Kevin M, Carleton Neil, Savariau Laura, Atkinson Jennifer M, Oesterreich Steffi, Lee Adrian V

Abstract excerpt

Invasive lobular breast carcinoma (ILC), one of the major breast cancer histologic subtypes, exhibits unique features compared with the well-studied ductal cancer subtype (IDC). The pathognomonic feature of ILC is loss of E-cadherin, mainly caused by inactivating mutations, but the contribution of this genetic alteration to ILC-specific molecular characteristics remains largely understudied. To profile these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ductal, Breast

Share to Carcinoma, Lobular

Share to Gene Expression Regulation, Neoplastic

Share to Single-Cell Analysis

Share to Transcriptome

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 33148662
DOI: 10.1158/0008-5472.CAN-20-0696
PMCID: PMC7856056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells.PMID 33148662Read ↗

Single cell transcriptomic heterogeneity in invasive ductal and lobular breast cancer cellsSemantic proximity Read ↗

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutationsSemantic proximity Read ↗

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic opportunitiesSemantic proximity Read ↗

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversitySemantic proximity Read ↗

Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.Semantic proximity Read ↗

Defining the regulatory logic of breast cancer using single-cell epigenetic and transcriptome profilingSemantic proximity Read ↗

Cellular stemness identifies high-risk ductal carcinoma <i>in situ</i> and offers a therapeutic interception opportunitySemantic proximity Read ↗

A highly resolved integrated single-cell atlas of human breast cancersSemantic proximity Read ↗

Single-Cell RNA-Sequencing: Opening New Horizons for Breast Cancer ResearchSemantic proximity Read ↗

A spatially resolved single cell genomic atlas of the adult human breastSemantic proximity Read ↗

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.Semantic proximity Read ↗

Single‐cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.