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Lobular breast cancer: molecular basis, mouse and cellular models

7 Feb 2015

Abstract excerpt

Infiltrating lobular breast cancer (ILC) is the most common special breast cancer subtype. With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being confined almost exclusively to ILC, this tumor entity stands out from all other types of breast cancers. The molecular basis of ILC is linked to loss of E-cadherin, as evidenced by human CDH1 germline mutations and conditional...

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Cancer Cells and Metastasis
Infectious Diseases and Mycology
Wnt/β-catenin signaling in development and cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25757734
DOI: 10.1186/s13058-015-0517-z

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