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Insights into E-Cadherin Impairment in CDH1-Unaltered Invasive Lobular Carcinoma: A Comprehensive Bioinformatic Study.

International journal of molecular sciences - 17 Aug 2024

Uchida Shiro, Sugino Takashi

Abstract excerpt

Invasive lobular carcinoma exhibits unique morphological features frequently associated with alterations in CDH1. Although some studies have identified abnormalities in adhesion factors other than E-cadherin, the molecular mechanisms underlying E-cadherin abnormalities in CDH1-unaltered invasive lobular carcinoma remain poorly understood. In this study, we investigated the molecular underpinnings of E-cadherin...

Topics

Cadherins
Carcinoma, Lobular
Humans
Antigens, CD
Computational Biology
Female
Breast Neoplasms
Gene Expression Regulation, Neoplastic
DNA Methylation
Mutation
MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Neoplasm Invasiveness

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Identifiers

PMID: 39201647
DOI: 10.3390/ijms25168961
PMCID: PMC11354486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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