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Article

E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020

Christgen Matthias, Bartels Stephan, van Luttikhuizen Jana L, Bublitz Janin, Rieger Luisa U, Christgen Henriette, Stark Helge, Sander Bjoern, Lehmann Ulrich, Steinemann Doris, Derksen Patrick W B, Kreipe Hans

Abstract excerpt

Loss of E-cadherin expression due to mutation of the CDH1 gene is a characteristic feature of invasive lobular breast cancer (ILBC). Beta-catenin, which binds to the cytoplasmic domain of E-cadherin, is simultaneously downregulated, reflecting disassembly of adherens junctions (AJs) and loss of cell adhesion. E-cadherin to P-cadherin expression switching can rescue AJs and cell adhesion. However, P-cadherin has...

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Identifiers

PMID: 32572153
DOI: 10.1038/s41379-020-0591-3
PMCID: PMC7685979

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