Article

Cellular stemness identifies high-risk ductal carcinoma <i>in situ</i> and offers a therapeutic interception opportunity

2026-05-16

Abstract excerpt

Ductal carcinoma in situ (DCIS) exhibits substantial heterogeneity in its risk of progression to invasive breast cancer, yet the cellular and molecular determinants of high-risk lesions remain incompletely defined. Using spatially resolved single-cell transcriptomic and epigenomic profiling of 43 patient-derived DCIS and DCIS/invasive ductal carcinoma (IDC) samples, we delineate cellular programs, spatial organiza...

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Literature Corpus work: 6a0c8eaa-fc91-5baa-b7ed-3d503edb3cf7
DOI: 10.64898/2026.05.13.724882

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