Article

Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma

2022-02-22

Abstract excerpt

No Special Type breast cancer (NST; commonly known as Invasive Ductal Carcinoma (IDC)) and Invasive Lobular Carcinoma (ILC) are the two major histological subtypes of breast cancer with significant differences in clinicopathological and molecular characteristics. The defining pathognomonic feature of ILC is loss of cellular adhesion protein, E-cadherin ( CDH1 ). We have previously shown that E-cadherin functions...

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Literature Corpus work: 95def1e6-4c75-503e-b9f1-96069fb3661b
DOI: 10.1101/2022.02.22.480917

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