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Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations

12 Feb 2024

Abstract excerpt

CDH1 (E-cadherin) bi-allelic inactivation is the hallmark alteration of breast invasive lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset of ILCs, however, lack CDH1 genetic/epigenetic inactivation, and their genetic underpinning is unknown. Through clinical targeted sequencing data reanalysis of 364 primary ILCs, we identified 25 ILCs lacking CDH1 bi-allelic genetic alterations. CDH1...

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PMID: 38347189
DOI: 10.1038/s41698-024-00508-x

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