Article

Lineage tracing using a Cas9-deaminase barcoding system targeting endogenous L1 elements

2018-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Determining cell lineage and function is critical to understanding human physiology and pathology. Although advances in lineage tracing methods have provided new insight into cell fate, defining cellular diversity at the mammalian level remains a challenge. Here, we developed a genome editing strategy using a cytidine deaminase fused with inactive Cas9 (dCas9) to specifically target endogenous i...

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Literature Corpus work: 249782dd-cad1-51ec-9391-3a5af85bb2c9
DOI: 10.1101/367177

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