Article
Lineage tracing and analog recording in mammalian cells by single-site DNA writing.
Nature chemical biology - 1 Jun 2021
Loveless Theresa B, Grotts Joseph H, Schechter Mason W, Forouzmand Elmira, Carlson Courtney K, Agahi Bijan S, Liang Guohao, Ficht Michelle, Liu Beide, Xie Xiaohui, Liu Chang C
Abstract excerpt
Studying cellular and developmental processes in complex multicellular organisms can require the non-destructive observation of thousands to billions of cells deep within an animal. DNA recorders address the staggering difficulty of this task by converting transient cellular experiences into mutations at defined genomic sites that can be sequenced later in high throughput. However, existing recorders act...
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