Article

Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR

2024-01-07

Abstract excerpt

Single cell lineage tracing, essential for unraveling cellular dynamics in disease evolution is critical for developing targeted therapies. CRISPR-Cas9, known for inducing permanent and cumulative mutations, is a cornerstone in lineage tracing. The novel homing guide RNA (hgRNA) technology enhances this by enabling dynamic retargeting and facilitating ongoing genetic modifications. Charting these mutations, especi...

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Literature Corpus work: 0983134c-42de-5544-8841-7d3884f26c19
DOI: 10.1101/2024.01.05.574236

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