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Article

Simulation of CRISPR-Cas9 editing on evolving barcode and accuracy of lineage tracing.

Scientific reports - 19 Aug 2024

Liu Fengshuo, Zhang Xiang, Yang Yipeng

Abstract excerpt

We designed a simulation program that mimics the CRISPR-Cas9 editing on evolving barcode and double strand break repair procedure along with cell divisions. Emerging barcode mutations tend to build upon previously existing mutations, occurring sequentially with each generation. This process results in a unique mutation profile in each cell. We sample the barcodes in leaf cells and reconstruct the lineage,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39160220
DOI: 10.1038/s41598-024-70154-7
PMCID: PMC11333585

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