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Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants.

Cell stem cell - 2 Jul 2026

Kang Zhixin, Chen Hui, Li Siyang, Wang Shou-Wen, Zhou Bin

Abstract excerpt

Elucidating cell fate decision-making requires linking lineage history to dynamic phenotypic states. Driven by single-cell sequencing and genome engineering, lineage tracing has evolved from observational studies into a multidimensional, high-throughput discipline. Here, we synthesize its three methodological pillars: prospective tracking via genetic markers, high-throughput mapping using synthetic barcodes, and...

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PMID: 42214336
DOI: 10.1016/j.stem.2026.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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