Article
Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Oct 2023
Dobrovolsky Vasily N, Matsuda Tomonari, McKinzie Page, Miranda Jaime, Revollo Javier R
Abstract excerpt
Direct DNA sequencing can be used for characterizing mutagenicity in simple and complex biological models. Recently we described a method of whole-genome sequencing for detecting mutations in simple models of cultured bacteria, mammalian cells, and nematode. In the current proof-of-concept study, we expand and improve our method for evaluating a more complex mammalian biological model in outbred mice. We detail...
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