Article

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

2021-07-10

Abstract excerpt

GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyperactivation to pathology we evaluated genetic and pharmacological approaches suppressing TREM2 dependent transition of microglia from a homeostatic to a disease associated state. Trem2 deficiency in Grn KO mice led...

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Literature Corpus work: c851d977-147c-5fc0-8308-f4dc42cf3218
DOI: 10.1101/2021.07.08.451574

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