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Article

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.

Communications biology - 1 Jul 2025

Clelland Claire Dudley, Fan Li, Saloner Rowan, Etchegaray Jon Iker, Altobelli Chad Richard, Salomonsson Sally, Maltos Alisha M, Sachdev Aradhana, Zhu Jingjie, Lee Se-In, Li Yaqiao, Zhou Yungui, Le David, Wang Chao, Carling Gillian, Kodama Lay, Sayed Faten, Perez-Bermejo Jaun A, Geier Ethan G, Yokoyama Jennifer S, Rosen Howie, Nana Alissa L, Spina Salvatore, Grinberg Lea T, Seeley William W, Elahi Fanny, Boxer Adam L, Arkin Michelle R, Gan Li

Abstract excerpt

Genetic mutations in the progranulin gene, GRN, cause frontotemporal dementia and a lysosomal storage disorder. Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant (GRN+/-) carriers we find dysregulation of microglia, phagocytosis and the phagocytic receptors MERTK and AXL. Exogenous progranulin regulates MERTK and AXL RNA expression in human...

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Identifiers

PMID: 40596721
DOI: 10.1038/s42003-025-08368-2
PMCID: PMC12218935

Genes

AXL
MERTK
GRN
C9ORF72
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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