Back to search

Article

A MICROGLIAL ACTIVITY STATE BIOMARKER PANEL DIFFERENTIATES FTD-GRANULIN AND ALZHEIMER’S DISEASE PATIENTS FROM CONTROLS

2023-06-18

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglial activation states. <h4>Methods</h4> Using mouse models and human induced pluripotent stem cell-derived microglia (hiMGL), which were genetically modified to yield the most opposite homeostatic ( TREM2- knockout) and disease-associated ( GRN -knockout)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
30eb6313-9e10-5bb8-8164-b08b8bf272f5
DOI
10.1101/2023.06.15.545187
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A MICROGLIAL ACTIVITY STATE BIOMARKER PANEL DIFFERENTIATES FTD-GRANULIN AND ALZHEIMER’S DISEASE PATIENTS FROM CONTROLSDOI 10.1101/2023.06.15.545187
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controlsSemantic proximity
The proteomic landscape of microglia in health and diseaseSemantic proximity
Deep proteomic analysis of microglia reveals fundamental biological differences between model systemsSemantic proximity
Signatures of glial activity can be detected in the CSF proteomeSemantic proximity
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
Shifting paradigms: The central role of microglia in Alzheimer's disease.Semantic proximity
Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s diseaseSemantic proximity
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.Semantic proximity
Microglial Responses to Alzheimer's Disease Pathology: Insights From “Omics” StudiesSemantic proximity
Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.Semantic proximity
HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures <i>in vitro</i>Semantic proximity
Select a neighboring publication to make it the new centre.