Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway

7 Oct 2021

Abstract excerpt

Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein progranulin (PGRN), are associated with several neurodegenerative diseases, including frontotemporal lobar degeneration, neuronal ceroid lipofuscinosis, and Alzheimer's disease. These genetic alterations manifest in pathological changes due to a reduction of PGRN expression; therefore, identifying factors that can modulate PGRN levels in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Amyotrophic Lateral Sclerosis Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34618685
DOI: 10.1172/jci.insight.136147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathwayPMID 34618685Read ↗

Nemo-like kinase regulates Progranulin levels in the brain through the microglial endocytosis-lysosomal pathwaySemantic proximity Read ↗

Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative DiseasesSemantic proximity Read ↗

PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseasesSemantic proximity Read ↗

A multifaceted role of progranulin in regulating amyloid-beta dynamics and responsesSemantic proximity Read ↗

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.Semantic proximity Read ↗

The lysosomal function of progranulin, a guardian against neurodegeneration.Semantic proximity Read ↗

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal ProteinSemantic proximity Read ↗

Progranulin deficiency perturbs lipid metabolism in white matter microgliaSemantic proximity Read ↗

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTDSemantic proximity Read ↗

Progranulin deficiency induces lipid droplet accumulation in microglia via a STAT3-GPAT3 axisSemantic proximity Read ↗

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Semantic proximity Read ↗

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.