Article
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Mar 2013
Filiano Anthony J, Martens Lauren Herl, Young Allen H, Warmus Brian A, Zhou Ping, Diaz-Ramirez Grisell, Jiao Jian, Zhang Zhijun, Huang Eric J, Gao Fen-Biao, Farese Robert V, Roberson Erik D
Abstract excerpt
Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in social and emotional function. Heterozygous loss-of-function mutations in GRN, the progranulin gene, are a common genetic cause of the disorder, but the mechanisms by which progranulin haploinsufficiency causes neuronal dysfunction in FTD are unclear. Homozygous progranulin knock-out (Grn(-/-)) mice have been studied as a model...
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