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A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

29 Sept 2023

Abstract excerpt

BACKGROUND: With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglial activation states. METHODS: Using mouse models and human induced pluripotent stem cell-derived microglia (hiMGL), genetically modified to yield the most opposite homeostatic (TREM2-knockout) and disease-associated (GRN-knockout) states, we identified microglia activity-dependent...

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PMID: 37775827
DOI: 10.1186/s13024-023-00657-w

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