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Article

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

8 Oct 2012

Abstract excerpt

Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In humans, PGRN haploinsufficiency is a major inherited cause of frontotemporal dementia (FTD), but how PGRN deficiency causes neurodegeneration is unknown. Here we show that loss of PGRN results in increased neuron loss in response to injury in the CNS. When exposed acutely to...

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PMID: 23041626
DOI: 10.1172/jci63113

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