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Article

Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases

11 Mar 2019

Abstract excerpt

Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new treatments. The complexity of neurodegenerative disease mechanisms can be highlighted by accumulating evidence for a role for a growth factor, progranulin (PGRN). PGRN is a glycoprotein encoded by the GRN/Grn gene with multiple cellular functions, including neurotrophic, anti-inflammatory and lysosome regulatory properties....

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PMID: 30862089
DOI: 10.3390/cells8030230

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