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Article

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

2025-08-01

Abstract excerpt

Mammalian SWI/SNF (BAF) chromatin remodeling complexes modulate DNA accessibility and gene expression, however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT (SWI/SNF Ig-Fold for Transcription Factor Interactions), a conserved, broad transcription factor (TF) binding platform on the SMARCD subunits. SWIFT is necessary and sufficient for direct engagement with the transa...

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Identifiers and source

Literature Corpus work
c82ed640-37b5-5218-b068-be211a4e10ce
DOI
10.1101/2025.08.01.667725
Open publication

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A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platformDOI 10.1101/2025.08.01.667725
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