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Article

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.

Science (New York, N.Y.) - 2 Apr 2026

Jain Siddhant U, Williamson Kaylyn E, Ying Alexander W, Turner Aasha M, Jiang Ruidong Jerry, Raval Shaunak, So Kevin, Allison Maxwell J, Sankar Akshay, Sáme Guerra Daniel D, Lin Yutong, Jiang Zhe, Mashtalir Nazar, Rohrs Henry W, Lichti Cheryl F, Muir Tom W, Papanastasiou Malvina, Paulo Joao A, Gygi Steven P, Gross Michael L, Kadoch Cigall

Abstract excerpt

Mammalian switch/sucrose nonfermenting (mSWI/SNF) chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT [SWI/SNF immunoglobulin fold (Ig-fold) for transcription factor interactions], a conserved transcription factor (TF) binding domain on the SMARCD subunits. SWIFT is necessary and...

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Identifiers

PMID: 41477818
DOI: 10.1126/science.aeb3627
PMCID: PMC13276876

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TF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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