Article
The spectrum of SWI/SNF mutations, ubiquitous in human cancers.
PloS one - 1 Jan 2013
Shain A Hunter, Pollack Jonathan R
Abstract excerpt
SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating evidence suggests that SWI/SNF functions as a tumor suppressor in some cancers. However, the spectrum of SWI/SNF mutations acr...
Topics
- Chromosomal Proteins, Non-Histone
- Data Mining
- Exome
- Humans
- Mutation
- Neoplasms
- Transcription Factors
- Tumor Suppressor Protein p53