Article

Extracellular Ligand-Responsive Translational Regulation of Synthetic mRNAs using Engineered Receptors

2024-09-28

Abstract excerpt

mRNA drugs can encode any protein and are regarded as a promising therapeutic modality. In this study, we developed a new mRNA system allowing extracellular ligand-responsive translational regulation. This system consists of three mRNAs, two of which encode components for detecting extracellular ligands, and the other encodes the protein of interest, with a binding motif on 5’UTR for translational regulation. In t...

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Identifiers and source

Literature Corpus work: 8a2708f8-dbdb-5159-8ada-d8dd85bfbe2c
DOI: 10.1101/2024.09.27.615322

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