Article

NRF2 Regulates Contractile Vascular Smooth Muscle Cells Phenotypic Switching In Abdominal Aortic Aneurysm

2023-08-28

Abstract excerpt

<h4>OBJECTIVE</h4> Evidence from previous studies has demonstrated that NRF2 can protect cardiovascular progression,which prompted us to study if NRF2 is involved in AAA development. <h4>APPROACH AND RESULTS</h4> The difference and function of NRF2 in AAA were verified on human aortic tissues combined with scRNA-seq samples.We then used angiotensin II (Ang II) infusion mouse model with VSMCs-specific knockout to...

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Literature Corpus work: 53378912-671e-5b00-9987-c7dc25691219
DOI: 10.1101/2023.08.25.554907

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