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Metformin Stabilizes the Abdominal Aorta in Aneurysm by Restoring VSMC Mitochondrial Homeostasis via the AMPK–SIRT1–PGC-1α Axis

2026-03-02

Abstract excerpt

<h4>BACKGROUND</h4> Abdominal aortic aneurysm (AAA) is a life-threatening condition with >80% mortality upon rupture and no effective pharmacotherapy available. Despite epidemiological evidence linking metformin use to reduced AAA progression, its mechanism remains elusive. Notably, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α, encoded by Ppargc1a ) is downregulated in human AAA, yet its f...

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Literature Corpus work: 00c88282-f2f0-568e-9cec-d3e0f56dad8b
DOI: 10.64898/2026.02.27.708352

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