Article

PET-Microplastics Trigger Endothelial Glycocalyx Loss via ER Stress and ROS Unleashing IL-1β-Driven SMC Switching and Early Aortic Structural Impairment

2025-11-11

Abstract excerpt

<title>Abstract</title> <p>Polyethylene terephthalate microplastics (PET-MPs), a major microplastics component identified in human vasculature, pose emerging environmental health risks. This study systemically profiled MPs in human aortic tissues and investigated the mechanisms underlying PET-MPs-induced aortic injury in vivo and in vitro. Chronic oral exposure of Sprague-Dawley rats to PET-MPs (1.0-100 mg/L) res...

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Literature Corpus work: 5b11616f-d130-5889-a34b-e349365cc007
DOI: 10.21203/rs.3.rs-7770279/v1

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