Article
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Experimental & molecular medicine - 1 Sept 2020
Jeong Se-Jin, Cho Min Ji, Ko Na Young, Kim Sinai, Jung In-Hyuk, Min Jeong-Ki, Lee Sang Hak, Park Jong-Gil, Oh Goo Taeg
Abstract excerpt
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease characterized by structural deterioration of the aorta caused by inflammation and oxidative stress, leading to aortic dilatation and rupture. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, has been reported as a potential negative regulator of inflammatory vascular diseases, and it has been identified as a protein that is increased in patients...
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