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Article

Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High Mobility Group Box 1 Production and Inhibit Abdominal Aortic Aneurysms.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Sharma Ashish K, Salmon Morgan D, Lu Guanyi, Su Gang, Pope Nicolas H, Smith Joseph R, Weiss Mark L, Upchurch Gilbert R

Abstract excerpt

OBJECTIVE: Abdominal aortic aneurysm (AAA) formation is characterized by inflammation, smooth muscle activation, and matrix degradation. This study tests the hypothesis that macrophage-produced high mobility group box 1 (HMGB1) production is dependent on nicotinamide adenine dinucleotide phosphate oxidase (Nox2), which leads to increase in interleukin (IL)-17 production resulting in AAA formation and that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HMGB1 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 26988591
DOI: 10.1161/ATVBAHA.116.307373
PMCID: PMC4861899

Genes

HMGB1
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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