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Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues

2025-07-04

Abstract excerpt

The spatial resolution of omics dynamics is fundamental to understanding tissue biology. Spatial profiling of DNA methylation, which is a canonical epigenetic mark extensively implicated in transcriptional regulation, remains an unmet demand. Here, we introduce a method for whole genome spatial co-profiling of DNA methylation and transcriptome of the same tissue section at near single-cell resolution. Applying thi...

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Literature Corpus work
c80862f5-5080-57a8-8a54-3e27054e94d1
DOI
10.1101/2025.07.01.662607
Open publication

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Spatial joint profiling of DNA methylome and transcriptome in mammalian tissuesDOI 10.1101/2025.07.01.662607
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