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Article

Dynamic epigenomic landscapes during early lineage specification in mouse embryos.

Nature genetics - 1 Jan 2018

Zhang Yu, Xiang Yunlong, Yin Qiangzong, Du Zhenhai, Peng Xu, Wang Qiujun, Fidalgo Miguel, Xia Weikun, Li Yuanyuan, Zhao Zhen-Ao, Zhang Wenhao, Ma Jing, Xu Feng, Wang Jianlong, Li Lei, Xie Wei

Abstract excerpt

In mammals, all somatic development originates from lineage segregation in early embryos. However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell fate commitment remains poorly characterized. Here we report a comprehensive investigation of transcriptomes and base-resolution methylomes for early lineages in peri- and postimplantation mouse embryos. We found allele-specific and...

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PMID: 29203909
DOI: 10.1038/s41588-017-0003-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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