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Spatial Epigenome Sequencing at Tissue Scale and Cellular Level

2021-03-12

Abstract excerpt

Spatial biology is emerging as a new frontier of biomedical research in development and disease, but currently limited to transcriptome and a panel of proteins. Here we present spatial epigenome profiling for three histone modifications (H3K27me3, H3K4me3, H3K27ac) via next-generation sequencing by combining in-tissue CUT&Tag chemistry and microfluidic deterministic barcoding. Spatial chromatin states in mouse emb...

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Literature Corpus work
580c7630-8423-52ae-8197-837e0eace0fa
DOI
10.1101/2021.03.11.434985
Open publication

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Spatial Epigenome Sequencing at Tissue Scale and Cellular LevelDOI 10.1101/2021.03.11.434985
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