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Spatial profiling of chromatin accessibility in mouse and human tissues

17 Aug 2022

Abstract excerpt

Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context 1 . The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping 2–5 , but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we describe a method for...

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PMID: 35978191
DOI: 10.1038/s41586-022-05094-1

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