Article

Spatial 5mC-seq profiling of embryos and decidua after implantation in mammal

2025-12-17

Abstract excerpt

DNA methylation plays key roles in development and diseases. However, no spatial DNA methylation profiling technology has been reported until now. Here, we developed a spatial 5mC-seq method (SmC-seq) based on a microfluidic system. The SmC-seq can provide a non-biased genome-wide methylome at about single-cell scale (10 μm in width per channel). We further applied this SmC-seq to explore the spatiotemporal dynami...

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Literature Corpus work: bd03beb0-3b8b-56ab-8dc7-45a0d6cedbea
DOI: 10.64898/2025.12.15.694289

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