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Ultra high-throughput whole-genome methylation sequencing reveals trajectories in precancerous polyps to early colorectal adenocarcinoma

2022-05-30

Abstract excerpt

Aberrant shifts in DNA methylation have long been regarded as an early marker for cancer onset and progression. To chart DNA methylation changes that occur during the transformation from normal healthy colon tissue to malignant colorectal cancer (CRC), we collected over 50 samples from 15 familial adenomatous polyposis (FAP) and non-FAP colorectal cancer patients, and generated 30-70x whole-genome methylation sequ...

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Literature Corpus work
fcc0eb45-fa99-5601-8e6e-7d37c1d498d1
DOI
10.1101/2022.05.30.494076
Open publication

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Ultra high-throughput whole-genome methylation sequencing reveals trajectories in precancerous polyps to early colorectal adenocarcinomaDOI 10.1101/2022.05.30.494076
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