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Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors

2023-03-12

Abstract excerpt

Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression from precursor lesions toward malignancy. Leveraging spatial molecular information to construct a phylogeographic map of tumor evolution can reveal individualized growth trajectories with diagnostic and therapeutic potential. Integrative analysis of spatial multi-omic data from 31 colorectal specimens revealed simultaneous mic...

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Identifiers and source

Literature Corpus work
6661f19c-2c7f-5c4e-aeff-36ce5572b462
DOI
10.1101/2023.03.09.530832
Open publication

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Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumorsDOI 10.1101/2023.03.09.530832
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