Article
Large differences in global transcriptional regulatory programs of normal and tumor colon cells.
BMC cancer - 24 Sept 2014
Cordero David, Solé Xavier, Crous-Bou Marta, Sanz-Pamplona Rebeca, Paré-Brunet Laia, Guinó Elisabet, Olivares David, Berenguer Antonio, Santos Cristina, Salazar Ramón, Biondo Sebastiano, Moreno Víctor
Abstract excerpt
BACKGROUND: Dysregulation of transcriptional programs leads to cell malfunctioning and can have an impact in cancer development. Our study aims to characterize global differences between transcriptional regulatory programs of normal and tumor cells of the colon. METHODS: Affymetrix Human Genome U219 expression arrays were used to assess gene expression in 100 samples of colon tumor and their paired adjacent...
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