Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

Abstract excerpt

Chemokines and their receptors mediate cell migration and coordinate immune responses, while dysregulation can lead to inflammation. Therapeutic modulation of the chemokine signaling axis has proven difficult. Most drug discovery efforts target the receptors, whereas natural regulatory mechanisms focus on the chemokines. Despite this insight, development of effective chemokine-directed modulators has remained elus...

Topics

Open a Topic to create a Post that cites this publication.

• Amino Acid Sequence
• Chemokine receptors and signaling
• Chemokines, CC
• Glycosylation and Glycoproteins Research
• Molecular Dynamics Simulation
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

c7bd8fbc-313d-5f78-bc26-06369aa6794a

DOI

10.64898/2026.01.23.701245