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Article

Rational Design of High Affinity Interaction Between CC Chemokine Binding Protein vCCI and CCL17/TARC.

Biochemistry - 17 Sept 2024

Guan Wenyan, Stark Lauren E, Zhang Ning, Bains Arjan, Martinez Airam, Dupureur Cynthia M, Colvin Michael E, LiWang Patricia J

Abstract excerpt

The poxvirus-derived protein vCCI (viral CC chemokine inhibitor) binds almost all members of the CC chemokine family with nanomolar affinity, inhibiting their pro-inflammatory actions. Understanding the affinity and specificity of vCCI could lead to new anti-inflammatory therapeutics. CCL17, also known as TARC, is unusual among CC chemokines by having only micromolar binding to vCCI. We have used sequence...

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Identifiers

PMID: 39194151
DOI: 10.1021/acs.biochem.4c00298
PMCID: PMC11411725

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