Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

18 Aug 2025

Abstract excerpt

The G protein-coupled chemokine receptor CCR9 plays a major role in inflammatory bowel disease and is implicated in cancer. Despite its therapeutic relevance, the mechanism by which CCR9 is activated by its endogenous chemokine CCL25 remains poorly understood. Here, we combine structural modeling with multimodal pharmacological analysis of CCR9 mutants to map the CCR9-CCL25 interface and delineate key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40825773
DOI: 10.1038/s41467-025-62321-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mappingPMID 40825773Read ↗

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mappingSemantic proximity Read ↗

Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteinsSemantic proximity Read ↗

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28Semantic proximity Read ↗

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.Semantic proximity Read ↗

The Expanding Therapeutic Perspective of CCR5 BlockadeSemantic proximity Read ↗

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5Semantic proximity Read ↗

Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines.Semantic proximity Read ↗

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.Semantic proximity Read ↗

Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction networkSemantic proximity Read ↗

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.Semantic proximity Read ↗

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment.Semantic proximity Read ↗

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.