Article

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

2024-06-04

Abstract excerpt

The G protein-coupled CC chemokine receptor 9 (CCR9) plays a major role in inflammatory bowel disease and has been implicated in cancer. Despite its importance as a drug target, there is limited mechanistic understanding of how CCR9 engages and is activated by its endogenous chemokine agonist CCL25. Here, by combining structural modeling with multimodal pharmacological assessment of receptor mutants, we generated...

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Literature Corpus work: 952803e7-40e3-503c-b37b-6c5e3a309ebf
DOI: 10.1101/2024.06.04.596985

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