Article

AI assisted Design of Ligands for Lipocalin-2

2025-05-19

Abstract excerpt

Lipocalin-2 (LCN2) is an acute-phase glycoprotein whose upregulation is linked to blood– brain-barrier breakdown and neuroinflammation, making it an attractive diagnostic and therapeutic target. We developed an end-to-end, AI-guided workflow to rapidly design de-novo miniproteins that bind LCN2. Backbone scaffolds were generated with RFdiffusion, sequences were optimized with ProteinMPNN, and candidates filtered...

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Literature Corpus work: 2cd3c81c-6181-5d6d-95a6-0ced2ed48214
DOI: 10.1101/2025.05.18.654718

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