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Article

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.

PLoS biology - 1 Apr 2020

Ngo Tony, Stephens Bryan S, Gustavsson Martin, Holden Lauren G, Abagyan Ruben, Handel Tracy M, Kufareva Irina

Abstract excerpt

Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the barriers for their therapeutic targeting is the limited understanding of the structural principles behind receptor-chemokine recognition and selectivity. The...

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Identifiers

PMID: 32271748
DOI: 10.1371/journal.pbio.3000656
PMCID: PMC7173943

Genes

CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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